Ashwagandha & Melatonin: A Powerful Combination For Sleep & The Brain  

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Last Updated on November 20, 2022 by theworldofsleepstaff

Ashwagandha and melatonin are two powerful herbal supplements that have long been used to promote health and wellbeing.

Ashwagandha is an ancient Ayurvedic herb traditionally used to restore balance, fight stress, and reduce inflammation. It contains compounds like withanolides and alkaloids known for their calming effects on the body. Melatonin is a hormone naturally produced by the body to regulate sleep. But is it possible to take them together?

Well it turns out ashwagandha & melatonin could be a powerful combination for helping you sleep better and boosting cognitive performance – however there are potential side effects too.

This article will explore the potential benefits of taking ashwagandha and melatonin together and any potential side effects.

Disclaimer: It’s important to note that these potential benefits are based on anecdotal evidence and some from scientific research, but they should not be taken as medical advice. Speaking with your doctor before starting new supplements or treatment plans is what we always recommend. Additionally, it is your responsibility to do due diligence.

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Are Melatonin And Ashwagandha The Same?

The short answer is no; melatonin and Ashwagandha are two different supplements that serve different purposes. Melatonin is a hormone produced naturally to help regulate the sleep cycle. It can also supplement people suffering from insomnia or jet lag.

On the other hand, Ashwagandha is a herb used for centuries in Ayurvedic medicine as a natural stress reliever and adaptogen. While it does not directly affect the sleep cycle, it can help reduce anxiety and improve overall wellbeing, which may indirectly affect sleep.

Therefore, while melatonin and Ashwagandha are not the same, they can be used together to help regulate the sleep cycle and reduce stress.

Taking Ashwagandha regularly can also help support healthy melatonin levels in the body, helping to ensure a good night’s rest!

Can You Combine Melatonin And Ashwagandha?

Yes, you can. Ashwagandha is an adaptogen herb used for centuries in Ayurvedic medicine to help the body cope with stress and anxiety. It also helps increase energy levels, improve sleep quality and boost mental clarity. Melatonin is a natural hormone produced by the pineal gland that helps regulate our circadian rhythm and sleep-wake cycle.

When taken together, Ashwagandha and melatonin can be a powerful combination to help improve sleep quality and promote overall wellbeing.

Ashwagandha helps reduce stress by calming the nervous system, while melatonin helps regulate our natural body clock and encourages more profound, restorative sleep. This combination of herbs can also help improve focus, reduce fatigue and increase energy levels.

It is important to note that while taking Ashwagandha and melatonin together may benefit some people, it is always best to consult your doctor before starting any new supplement regimen.

In addition, practising good sleep hygiene, such as avoiding screens before bed, limiting caffeine intake and creating a restful sleep environment, is essential.

Ultimately, combining Ashwagandha and melatonin should be a safe and natural way to support better sleep quality and overall wellbeing. However, if this combination could benefit you, you must consult your doctor for the best approach.

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AshwagandhaAnd Melatonin: The Potential Benefits

1. It May Promote Stress Reduction & Relaxation

First, let’s look at the potential benefits of combining these two supplements.

Taking both Ashwagandha and melatonin may help to reduce stress and promote relaxation. Additionally, it may help to improve mood.

Ashwagandha is known to help ease anxiety and reduce cortisol levels (the stress hormone). Melatonin may also help regulate sleep patterns, promoting a healthy mental state and improved mood.

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2. It May Improve Cognitive Function

Taking Ashwagandha and melatonin together may also have positive effects on cognitive function.

A study on mice found that Ashwagandha increased the number of neurons in the hippocampus, a part of the brain responsible for learning and memory.

Melatonin has also been shown to improve cognitive performance in animals and humans alike.

3. It May Improve Sleep Quality

Combining Ashwagandha and melatonin may help to promote a more restful night’s sleep.

Ashwagandha has been found to reduce the time it takes to fall asleep and increase the amount of deep sleep. Melatonin has also been shown to help people fall asleep faster and stay asleep longer.

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4. It May Reduce Inflammation

Ashwagandha and melatonin may help to reduce inflammation in the body.

Ashwagandha has been found to have anti-inflammatory properties, while melatonin has been shown to inhibit inflammatory processes. This can be beneficial for people suffering from chronic inflammation or autoimmune disorders.

5. It May Improve Overall Health

Finally, taking both Ashwagandha and melatonin may help to improve overall health. Ashwagandha is known for its adaptogenic properties, which help the body maintain balance in times of stress.

Melatonin also supports immune system function, which can lead to improved energy levels and better overall health. Zupancic

Ashwagandha and Melatonin: Possible Side Effects

While taking Ashwagandha and melatonin together may have some potential benefits, there are also some possible side effects to consider. Here are the most common ones:

1. May Cause Drowsiness

Ashwagandha and melatonin are two natural supplements that can cause drowsiness when taken together. Ashwagandha is a herb used in Ayurvedic medicine for centuries, while melatonin is a hormone produced by the pineal gland to regulate sleep cycles.

Combining the two can create a sedative effect, making it difficult to stay awake. This can be beneficial for people with insomnia or difficulty falling asleep but should not be taken during the day unless your doctor advises otherwise.

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2. May Interact With Other Medications

Ashwagandha and melatonin may interact with other medications, so it’s essential to discuss the use of these supplements with your doctor.

Ashwagandha can interfere with some heart drugs and diuretics, while melatonin may alter the effects of certain antidepressants, blood thinners, and diabetes medications.

It is also important to note that melatonin can decrease the effectiveness of birth control pills. It is essential to talk to your doctor before combining these supplements with any medications you are currently taking.

3. May Cause Increased Heart Rate

Both Ashwagandha and melatonin can have stimulating effects on the body. While these effects are often mild, they may cause an increased heart rate in some individuals.

Therefore, monitoring your heart rate when taking both supplements is essential, as too much stimulation could be dangerous for those with existing heart conditions or who take certain medications.

Additionally, before beginning any supplement regimen, it’s best to speak with a doctor.

3. May Cause Digestive Disturbances

The combination of Ashwagandha and melatonin may cause digestive disturbances in some individuals.

People who are sensitive to either product or have a history of gastrointestinal issues should be cautious while taking this supplement, as the combination could lead to an upset stomach or other gastrointestinal distress.

If you experience any adverse digestive side effects after taking these supplements, stop taking them and contact your doctor. Taking the recommended dosage of both supplements is key to avoiding potential digestive issues.

Additionally, taking Ashwagandha and melatonin with a meal or snack may be beneficial, as this can help reduce gastric discomfort.

Helpful Tips When Taking Ashwagandha and Melatonin

Ashwagandha and melatonin can be powerful supplements, so they should not be taken lightly. Here are a few tips to keep in mind when taking these two supplements

Speak to your doctor before beginning any supplement regimen. This is especially important if you have any existing health conditions or are taking medications.

Start with the lowest possible dose and increase gradually if needed. Taking too much of either supplement can lead to adverse side effects, so starting low is key

• Take Ashwagandha and melatonin with food for best results

Monitor your heart rate while taking the supplements, as too much stimulation could be dangerous.

Following these tips and speaking with your doctor before beginning any supplement regimen can ensure that Ashwagandha and melatonin are safe and effective. This powerful combination can help support optimal sleep cycles and improve overall health with proper use.

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How close to bedtime should I take Ashwagandha and melatonin?

Taking these supplements about 30 minutes before bedtime is best for optimal results. This will allow the sedative effects of both supplements to take effect, helping you drift off into a deep sleep.

Can I take Ashwagandha and melatonin during the day?

No, it is not recommended to take these supplements during the day. Both Ashwagandha and melatonin can have stimulating effects on the body, which could lead to an increased heart rate or other side effects if taken during the day.


The combination of Ashwagandha and melatonin is an interesting one, as it has the potential to improve sleep quality and cognitive performance.

While there are some possible side effects to consider when taking this supplement together, it may also offer a range of benefits for those looking to enhance their health naturally.

Before beginning any supplement regimen, you must talk to your doctor, who can help you decide if Ashwagandha and melatonin are the right choices. With careful monitoring and a healthy lifestyle, these two supplements may effectively improve sleep quality and overall health.